12 Roles That Became Both a Blessing and a Curse for the Actors Who Played Them
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Angela Lansbury as Jessica Fletcher, she had a wonderful list of magnificent films in fact too many to mention as some could be left out... however she'll always be remembered as the main character of Murder, She Wrote.

I guess Emilia Clarke can be added to the list, for many of us she will stay as Daenerys, for a couple of years at least

That's what you get for playing in super popular movies. For example, the main actor who played in Kommissar Rex decided to leave the cast because he didn't like how popular it became and how everyone recognized him only because of this role